Article

Single-Cell Imaging Maps Inflammatory Cell Subsets to Pulmonary Arterial Hypertension Vasculopathy

2022-12-05

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Rationale</h4> Elucidating the immune landscape within and surrounding pulmonary arteries (PAs) is critical in understanding immune-driven vascular pathology in pulmonary arterial hypertension (PAH). Although more severe vascular pathology is often observed in hereditary (H)PAH patients with BMPR2 mutations, the involvement of specific immune cell subsets remains unclear. <h4>Methods</h4>...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: df804d13-a124-5b99-9c3b-35275f4276e9
DOI: 10.1101/2022.12.03.518033

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-Cell Imaging Maps Inflammatory Cell Subsets to Pulmonary Arterial Hypertension VasculopathyDOI 10.1101/2022.12.03.518033Read

Single-cell characterization of the immune heterogeneity of pulmonary hypertension identifies novel targets for immunotherapySemantic proximity Read

Peripheral Blood Single-Cell Sequencing Uncovers Common and Specific Immune Aberrations in Fibrotic Lung DiseasesSemantic proximity Read

Integrated histopathology, spatial and single cell transcriptomics resolve cellular drivers of early and late alveolar damage in COVID-19Semantic proximity Read

Identification of immune‐associated signatures and potential therapeutic targets for pulmonary arterial hypertensionSemantic proximity Read

Cluster analysis reveals three clinical phenotypes of pulmonary artery hypertension associated with connective tissue diseases: insights into inflammation and immunity.Semantic proximity Read

Emergence of disease-specific endothelial and stromal cell populations responsible for arterial remodeling during development of pulmonary arterial hypertensionSemantic proximity Read

Myeloid HIF-1α Sustains Hypoxic Fibrotic Fronts and Drives Pulmonary FibrosisSemantic proximity Read

Single-cell landscape reveals NAMPT mediated macrophage polarization that regulate smooth muscle cell phenotypic switch in pulmonary arterial hypertensionSemantic proximity Read

The pleuroparenchymal fibroelastosis atlas reveals aberrant cell states and their zonation as an alternate roadmap to lung fibrosisSemantic proximity Read

Bioinformatics analysis of the immune cell infiltration characteristics and correlation with crucial diagnostic markers in pulmonary arterial hypertensionSemantic proximity Read

Monocyte Subset Predicts Clinical Outcomes in Fibrotic Hypersensitivity PneumonitisSemantic proximity Read

Stage-resolved Spatial Multi-omics Reveals Myeloid Niches in Human Atherosclerotic PlaquesSemantic proximity Read