Article
House dust mite-driven neutrophilic airway inflammation in mice with TNFAIP3-deficient myeloid cells is IL-17-independent.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Dec 2018
Vroman Heleen, Das Tridib, Bergen Ingrid M, van Hulst Jennifer A C, Ahmadi Fatemeh, van Loo Geert, Lubberts Erik, Hendriks Rudi W, Kool Mirjam
Abstract excerpt
BACKGROUND: Asthma is a heterogeneous disease of the airways that involves several types of granulocytic inflammation. Recently, we have shown that the activation status of myeloid cells regulated by TNFAIP3/A20 is a crucial determinant of eosinophilic or neutrophilic airway inflammation. However, whether neutrophilic inflammation observed in this model is dependent on IL-17 remains unknown. OBJECTIVE: In this...
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