Article
Relationship of APOE, age at onset, amyloid and clinical phenotype in Alzheimer disease.
Neurobiology of aging - 1 Dec 2021
Whitwell Jennifer L, Tosakulwong Nirubol, Weigand Stephen D, Graff-Radford Jonathan, Ertekin-Taner Nilufer, Machulda Mary M, Duffy Joseph R, Schwarz Christopher G, Senjem Matthew L, Jack Clifford R, Lowe Val J, Josephs Keith A
Abstract excerpt
The apolipoprotein E (APOE) ε4 allele is the most well-established risk factor for Alzheimer's disease (AD), although its relationship to age at onset and clinical phenotype is unclear. We aimed to assess relationships between APOE genotype and age at onset, amyloid-beta (Aβ) deposition and typical versus atypical clinical presentations in AD. Frequency of APOE ε4 carriers by age at onset was assessed in 447 AD...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.