Article

Cell-type specific open chromatin profiling in human postmortem brain infers functional roles for non-coding schizophrenia loci

2016-07-07

Abstract excerpt

<h4>SUMMARY</h4> To better understand the role of cis regulatory elements in neuropsychiatric disorders we applied ATAC-seq to neuronal and non-neuronal nuclei isolated from frozen postmortem human brain. Most of the identified open chromatin regions (OCRs) are differentially accessible between neurons and non-neurons, and show enrichment with known cell type markers, promoters and enhancers. Relative to those o...

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Literature Corpus work: bf0bdf19-d629-522f-b2d9-a3d6ef3fd6e7
DOI: 10.1101/062513

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