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Article

Mapping cis-regulatory elements in human neurons links psychiatric disease heritability and activity-regulated transcriptional programs.

Cell reports - 31 May 2022

Sanchez-Priego Carlos, Hu Ruiqi, Boshans Linda L, Lalli Matthew, Janas Justyna A, Williams Sarah E, Dong Zhiqiang, Yang Nan

Abstract excerpt

Genome-wide association studies (GWASs) have identified hundreds of loci associated with psychiatric diseases, yet there is a lack of understanding of disease pathophysiology. Common risk variants can shed light on the underlying molecular mechanisms; however, identifying causal variants remains challenging. We map cis-regulatory elements in human neurons derived from pluripotent stem cells. This system allows us...

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Identifiers

PMID: 35649373
DOI: 10.1016/j.celrep.2022.110877
PMCID: PMC9219592

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