Article

Allele-specific open chromatin in human iPSC neurons elucidates functional non-coding disease variants

2019-11-01

Abstract excerpt

Functional interpretation of noncoding disease variants, which likely regulate gene expression, has been challenging. Chromatin accessibility strongly influences gene expression during neurodevelopment; however, to what extent genetic variants can alter chromatin accessibility in the context of brain disorders/traits is unknown. Using human induced pluripotent stem cell (iPSC)-derived neurons as a neurodevelopment...

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Literature Corpus work: d2729162-a514-55ec-8ab4-22d25e32d783
DOI: 10.1101/827048

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