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Article

FEN1 endonuclease as a therapeutic target for human cancers with defects in homologous recombination

27 Jul 2020

Abstract excerpt

Significance Analysis of synthetic lethal relationships identified in Saccharomyces cerevisiae was used to identify candidate therapeutic targets for cancers with BRCA1 or BRCA2 defects. Inhibition of one of these targets, flap endonuclease 1 (FEN1), with small-molecule inhibitors or siRNA knockdown of FEN1 expression preferentially killed BRCA1 and BRCA2 mutant cancer cell lines as well as some additional cancer...

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PMID: 32719125
DOI: 10.1073/pnas.2009237117

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FEN1 endonuclease as a therapeutic target for human cancers with defects in homologous recombinationPMID 32719125Read ↗

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