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Article

Functional analysis of human FEN1 in Saccharomyces cerevisiae and its role in genome stability.

Human molecular genetics - 1 Nov 1999

Greene A L, Snipe J R, Gordenin D A, Resnick M A

Abstract excerpt

The flap endonuclease, FEN1, is an evolutionarily conserved component of DNA replication from archaebacteria to humans. Based on in vitro results, it processes Okazaki fragments during replication and is involved in base excision repair. FEN1 removes the last primer ribonucleotide on the lagging strand and it cleaves a 5' flap that may result from strand displacement during replication or during base excision...

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Source

Identifiers

PMID: 10545607
DOI: 10.1093/hmg/8.12.2263

Genes

FEN1
PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Functional analysis of human FEN1 in Saccharomyces cerevisiae and its role in genome stability.PMID 10545607Read ↗

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