Article
Haploinsufficiency of Flap endonuclease (Fen1) leads to rapid tumor progression.
Proceedings of the National Academy of Sciences of the United States of America - 23 Jul 2002
Kucherlapati Melanie, Yang Kan, Kuraguchi Mari, Zhao Jie, Lia Maria, Heyer Joerg, Kane Michael F, Fan Kunhua, Russell Robert, Brown Anthony M C, Kneitz Burkhard, Edelmann Winfried, Kolodner Richard D, Lipkin Martin, Kucherlapati Raju
Abstract excerpt
Flap endonuclease (Fen1) is required for DNA replication and repair, and defects in the gene encoding Fen1 cause increased accumulation of mutations and genome rearrangements. Because mutations in some genes involved in these processes cause cancer predisposition, we investigated the possibility that Fen1 may function in tumorigenesis of the gastrointestinal tract. Using gene knockout approaches, we introduced a...
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