Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Murine models of IDH-wild-type glioblastoma exhibit spatial segregation of tumor initiation and manifestation during evolution.

Nature communications - 22 Jul 2020

Li Yinghua, Li Bo, Li Wei, Wang Yuan, Akgül Seçkin, Treisman Daniel M, Heist Kevin A, Pierce Brianna R, Hoff Benjamin, Ho Cheng-Ying, Ferguson David O, Rehemtulla Alnawaz, Zheng Siyuan, Ross Brian D, Li Jun Z, Zhu Yuan

Abstract excerpt

Recent characterization of spatiotemporal genomic architecture of IDH-wild-type multifocal glioblastomas (M-GBMs) suggests a clinically unobserved common-ancestor (CA) with a less aggressive phenotype, generating highly genetically divergent malignant gliomas/GBMs in distant brain regions. Using serial MRI/3D-reconstruction, whole-genome sequencing and spectral karyotyping-based single-cell phylogenetic tree...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinogenesis
Share to Clonal Evolution

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glioblastoma

Share to Isocitrate Dehydrogenase

Share to Mechanistic Target of Rapamycin Complex 2

Share to Proto-Oncogene Proteins c-akt

Share to PTEN Phosphohydrolase

Share to Single-Cell Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 32699356
DOI: 10.1038/s41467-020-17382-3
PMCID: PMC7376246

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Murine models of IDH-wild-type glioblastoma exhibit spatial segregation of tumor initiation and manifestation during evolution.PMID 32699356Read ↗

Cryptic developmental events determine medulloblastoma radiosensitivity and cellular heterogeneity without altering transcriptomic profileSemantic proximity Read ↗

Evolutionary Trajectories of IDHWT Glioblastomas Reveal a Common Path of Early Tumorigenesis Instigated Years ahead of Initial DiagnosisSemantic proximity Read ↗

Genomic profiles of low-grade murine gliomas evolve during progression to glioblastoma.Semantic proximity Read ↗

Cryptic developmental events determine medulloblastoma radiosensitivity and cellular heterogeneity without altering transcriptomic profile.Semantic proximity Read ↗

Epigenetic states of cells of origin and tumor evolution drive tumor-initiating cell phenotype and tumor heterogeneity.Semantic proximity Read ↗

Comprehensive molecular characterization of multifocal glioblastoma proves its monoclonal origin and reveals novel insights into clonal evolution and heterogeneity of glioblastomas.Semantic proximity Read ↗

Pten and p53 converge on c-Myc to control differentiation, self-renewal, and transformation of normal and neoplastic stem cells in glioblastoma.Semantic proximity Read ↗

Convergence on BRAF and MAPK Signaling in Glioma Development in a P53-ENU modelSemantic proximity Read ↗

Mutant IDH1 Disrupts the Mouse Subventricular Zone and Alters Brain Tumor Progression.Semantic proximity Read ↗

Beyond Conventional Models: Recreating the Initiation, Evolution, and Genome of GBMSemantic proximity Read ↗

Mosaic analysis with double markers reveals tumor cell of origin in glioma.Semantic proximity Read ↗

A new genetically engineered transplant model of glioma recapitulates key phenotypes of low- and high-grade gliomasSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.