Article

Beyond Conventional Models: Recreating the Initiation, Evolution, and Genome of GBM

2019-11-09

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Imagining ways to prevent or treat glioblastoma (GBM) have been hindered by a lack of understanding of its pathogenesis. Although PDGF-AA overexpression may be an early event, critical details of the core biology are lacking. Existing PDGF-driven models replicate its microscopic appearance but not the genomic architecture characteristic of the human disease. Here we report a...

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Literature Corpus work: a6cca4c6-b6f5-550d-b265-0b7d0209e7da
DOI: 10.1101/837138

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