Article

Convergence on BRAF and MAPK Signaling in Glioma Development in a P53-ENU model

2026-02-23

Abstract excerpt

Pediatric high-grade gliomas (HGGs) are aggressive and lethal brain tumors that account for 15– 20% of all pediatric central nervous system (CNS) malignancies and remain largely incurable. These tumors, despite having mutational targets that activate MAPK signaling, are frequently resistant to targeted therapies in their malignant states, but often show responses when they are in lower grade form. These findings s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 967b4285-fb86-57f5-a2db-a12b2a5f9319
DOI: 10.64898/2026.02.23.707201

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Convergence on BRAF and MAPK Signaling in Glioma Development in a P53-ENU modelDOI 10.64898/2026.02.23.707201Read

Pediatric low-grade glioma in the era of molecular diagnostics.Semantic proximity Read

Braf Mutations Initiate the Development of Rat Gliomas Induced by Postnatal Exposure to N-Ethyl-N-Nitrosourea.Semantic proximity Read

Using neurofibromatosis-1 to better understand and treat pediatric low-grade glioma.Semantic proximity Read

Successes and challenges in modeling heterogeneous BRAFV600E mutated central nervous system neoplasmsSemantic proximity Read

Optimizing preclinical pediatric low-grade glioma models for meaningful clinical translation.Semantic proximity Read

Current Landscape of Preclinical Models for Pediatric Gliomas: Clinical Implications and Future DirectionsSemantic proximity Read

A diverse landscape of FGFR alterations and co-mutations defines novel therapeutic strategies in pediatric low-grade gliomasSemantic proximity Read

A diverse landscape of FGFR alterations and co-mutations suggests potential therapeutic strategies in pediatric low-grade gliomas.Semantic proximity Read

Pediatric gliomas as neurodevelopmental disorders.Semantic proximity Read

Origin of GliomasSemantic proximity Read

Pten and p53 converge on c-Myc to control differentiation, self-renewal, and transformation of normal and neoplastic stem cells in glioblastoma.Semantic proximity Read

Developmental origins of brain tumors.Semantic proximity Read