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Article

Epigenetic states of cells of origin and tumor evolution drive tumor-initiating cell phenotype and tumor heterogeneity.

Cancer research - 1 Sept 2014

Chow Kin-Hoe, Shin Dong-Mi, Jenkins Molly H, Miller Emily E, Shih David J, Choi Seungbum, Low Benjamin E, Philip Vivek, Rybinski Brad, Bronson Roderick T, Taylor Michael D, Yun Kyuson

Abstract excerpt

A central confounding factor in the development of targeted therapies is tumor cell heterogeneity, particularly in tumor-initiating cells (TIC), within clinically identical tumors. Here, we show how activation of the Sonic Hedgehog (SHH) pathway in neural stem and progenitor cells creates a foundation for tumor cell evolution to heterogeneous states that are histologically indistinguishable but molecularly...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25136069
DOI: 10.1158/0008-5472.CAN-13-3293
PMCID: PMC4154983

Genes

SHH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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