Article
Mosaic analysis with double markers reveals tumor cell of origin in glioma.
Cell - 22 Jul 2011
Liu Chong, Sage Jonathan C, Miller Michael R, Verhaak Roel G W, Hippenmeyer Simon, Vogel Hannes, Foreman Oded, Bronson Roderick T, Nishiyama Akiko, Luo Liqun, Zong Hui
Abstract excerpt
Cancer cell of origin is difficult to identify by analyzing cells within terminal stage tumors, whose identity could be concealed by the acquired plasticity. Thus, an ideal approach to identify the cell of origin is to analyze proliferative abnormalities in distinct lineages prior to malignancy. Here, we use mosaic analysis with double markers (MADM) in mice to model gliomagenesis by initiating concurrent p53/Nf1...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.