Article
Pten and p53 converge on c-Myc to control differentiation, self-renewal, and transformation of normal and neoplastic stem cells in glioblastoma.
Cold Spring Harbor symposia on quantitative biology - 1 Jan 2008
Zheng H, Ying H, Yan H, Kimmelman A C, Hiller D J, Chen A-J, Perry S R, Tonon G, Chu G C, Ding Z, Stommel J M, Dunn K L, Wiedemeyer R, You M J, Brennan C, Wang Y A, Ligon K L, Wong W H, Chin L, dePinho R A
Abstract excerpt
Glioblastoma (GBM) is a highly lethal primary brain cancer with hallmark features of diffuse invasion, intense apoptosis resistance and florid necrosis, robust angiogenesis, and an immature profile with developmental plasticity. In the course of assessing the developmental consequences of central nervous system (CNS)-specific deletion of p53 and Pten, we observed a penetrant acute-onset malignant glioma phenotype...
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