Article
Mutant IDH1 Disrupts the Mouse Subventricular Zone and Alters Brain Tumor Progression.
Molecular cancer research : MCR - 1 May 2017
Pirozzi Christopher J, Carpenter Austin B, Waitkus Matthew S, Wang Catherine Y, Zhu Huishan, Hansen Landon J, Chen Lee H, Greer Paula K, Feng Jie, Wang Yu, Bock Cheryl B, Fan Ping, Spasojevic Ivan, McLendon Roger E, Bigner Darell D, He Yiping, Yan Hai
Abstract excerpt
IDH1 mutations occur in the majority of low-grade gliomas and lead to the production of the oncometabolite, D-2-hydroxyglutarate (D-2HG). To understand the effects of tumor-associated mutant IDH1 (IDH1-R132H) on both the neural stem cell (NSC) population and brain tumorigenesis, genetically faithful cell lines and mouse model systems were generated. Here, it is reported that mouse NSCs expressing Idh1-R132H...
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