Article
Comprehensive molecular characterization of multifocal glioblastoma proves its monoclonal origin and reveals novel insights into clonal evolution and heterogeneity of glioblastomas.
Neuro-oncology - 1 Apr 2017
Abou-El-Ardat Khalil, Seifert Michael, Becker Kerstin, Eisenreich Sophie, Lehmann Matthias, Hackmann Karl, Rump Andreas, Meijer Gerrit, Carvalho Beatriz, Temme Achim, Schackert Gabriele, Schröck Evelin, Krex Dietmar, Klink Barbara
Abstract excerpt
Background: The evolution of primary glioblastoma (GBM) is poorly understood. Multifocal GBM (ie, multiple synchronous lesions in one patient) could elucidate GBM development. Methods: We present the first comprehensive study of 12 GBM foci from 6 patients using array-CGH, spectral karyotyping, gene expression arrays, and next-generation sequencing. Results: Multifocal GBMs genetically resemble primary GBMs....
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