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Article

MiR-185 targets POT1 to induce telomere dysfunction and cellular senescence

18 Jul 2020

Abstract excerpt

Protection of telomere 1 (POT1), the telomeric single-stranded DNA (ssDNA)-binding protein in the shelterin complex, has been implicated in the DNA damage response, tumorigenesis and aging. Telomere dysfunction induced by telomere deprotection could accelerate cellular senescence in primary human cells. While previous work demonstrated the biological mechanism of POT1 in aging and cancer, how POT1 is...

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PMID: 32687062
DOI: 10.18632/aging.103541

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