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Article

The telomere binding protein Pot1 maintains haematopoietic stem cell activity with age

2 Oct 2017

Abstract excerpt

Repeated cell divisions and aging impair stem cell function. However, the mechanisms by which this occurs are not fully understood. Here we show that protection of telomeres 1A (Pot1a), a component of the Shelterin complex that protects telomeres, improves haematopoietic stem cell (HSC) activity during aging. Pot1a is highly expressed in young HSCs, but declines with age. In mouse HSCs, Pot1a knockdown increases...

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Share to Hematopoietic Stem Cell Transplantation
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PMID: 28986560
DOI: 10.1038/s41467-017-00935-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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The telomere binding protein Pot1 maintains haematopoietic stem cell activity with agePMID 28986560Read ↗

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Role of POT1 in Human CancerSemantic proximity Read ↗

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Mice carrying the homologous human shelterin POT1-L259S mutation linked to pulmonary fibrosis show a telomerase deficiency-like phenotype with telomere shortening with increasing mouse generations.Semantic proximity Read ↗

Cancer-associated POT1 mutations lead to telomere elongation without induction of a DNA damage response.Semantic proximity Read ↗

Human shelterin protein POT1 prevents severe telomere instability induced by homology-directed DNA repair.Semantic proximity Read ↗

Active telomere elongation by a subclass of cancer-associated POT1 mutations.Semantic proximity Read ↗

POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes endSemantic proximity Read ↗

Distinct functions of POT1 proteins contribute to the regulation of telomerase recruitment to telomeresSemantic proximity Read ↗

Human POT1 Facilitates Telomere Elongation by TelomeraseSemantic proximity Read ↗

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