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Article

Inhibition of the oxygen sensor PHD2 in the liver improves survival in lactic acidosis by activating the Cori cycle.

Proceedings of the National Academy of Sciences of the United States of America - 15 Sept 2015

Suhara Tomohiro, Hishiki Takako, Kasahara Masataka, Hayakawa Noriyo, Oyaizu Tomoko, Nakanishi Tsuyoshi, Kubo Akiko, Morisaki Hiroshi, Kaelin William G, Suematsu Makoto, Minamishima Yoji Andrew

Abstract excerpt

Loss of prolyl hydroxylase 2 (PHD2) activates the hypoxia-inducible factor-dependent hypoxic response, including anaerobic glycolysis, which causes large amounts of lactate to be released from cells into the circulation. We found that Phd2-null mouse embryonic fibroblasts (MEFs) produced more lac...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26324945
DOI: 10.1073/pnas.1515872112
PMCID: PMC4577207

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-26324945-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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