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Dietary pyruvate targets cytosolic phospholipase A2 to mitigate inflammation and obesity in mice

19 Mar 2024

Abstract excerpt

Obesity has a multifactorial etiology and is known to be a state of chronic low-grade inflammation, known as meta-inflammation. This state is associated with the development of metabolic disorders such as glucose intolerance and nonalcoholic fatty liver disease. Pyruvate is a glycolytic metabolite and a crucial node in various metabolic pathways. However, its role and molecular mechanism in obesity and associated...

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PMID: 38512816
DOI: 10.1093/procel/pwae014

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