Article

Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult in mice

2022-06-17

Abstract excerpt

<h4>ABSTRACT</h4> Pyruvate is a critical intermediary metabolite in gluconeogenesis, lipogenesis, as well as NADH production. As a result, there is growing interest in targeting the mitochondrial pyruvate carrier (MPC) complex in liver and metabolic diseases. However, recent in vitro data indicate that MPC inhibition diverts glutamine/glutamate away from glutathione synthesis and toward glutaminolysis to compensa...

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Literature Corpus work: 6d4d286f-03e0-5bcc-b779-70c92e742b9d
DOI: 10.1101/2022.06.14.495517

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