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H3K27ac acetylome signatures reveal the epigenomic reorganization in remodeled non-failing human hearts

14 Jul 2020

Abstract excerpt

BACKGROUND: H3K27ac histone acetylome changes contribute to the phenotypic response in heart diseases, particularly in end-stage heart failure. However, such epigenetic alterations have not been systematically investigated in remodeled non-failing human hearts. Therefore, valuable insight into cardiac dysfunction in early remodeling is lacking. This study aimed to reveal the acetylation changes of chromatin...

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PMID: 32664951
DOI: 10.1186/s13148-020-00895-5

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