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Article

Dynamic DNA methylation orchestrates cardiomyocyte development, maturation and disease.

Nature communications - 22 Oct 2014

Gilsbach Ralf, Preissl Sebastian, Grüning Björn A, Schnick Tilman, Burger Lukas, Benes Vladimir, Würch Andreas, Bönisch Ulrike, Günther Stefan, Backofen Rolf, Fleischmann Bernd K, Schübeler Dirk, Hein Lutz

Abstract excerpt

The heart is a highly specialized organ with essential function for the organism throughout life. The significance of DNA methylation in shaping the phenotype of the heart remains only partially known. Here we generate and analyse DNA methylomes from highly purified cardiomyocytes of neonatal, adult healthy and adult failing hearts. We identify large genomic regions that are differentially methylated during...

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Identifiers

PMID: 25335909
DOI: 10.1038/ncomms6288
PMCID: PMC4220495

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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