Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Early adaptive chromatin remodeling events precede pathologic phenotypes and are reinforced in the failing heart.

Journal of molecular and cellular cardiology - 1 Nov 2021

Chapski Douglas J, Cabaj Maximilian, Morselli Marco, Mason Rosibel J, Soehalim Elizabeth, Ren Shuxun, Pellegrini Matteo, Wang Yibin, Vondriska Thomas M, Rosa-Garrido Manuel

Abstract excerpt

The temporal nature of chromatin structural changes underpinning pathologic transcription are poorly understood. We measured chromatin accessibility and DNA methylation to study the contribution of chromatin remodeling at different stages of cardiac hypertrophy and failure. ATAC-seq and reduced representation bisulfite sequencing were performed in cardiac myocytes after transverse aortic constriction (TAC) or...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiomegaly
Share to Chromatin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromatin Assembly and Disassembly

Share to Enhancer Elements, Genetic

Share to Epigenesis, Genetic

Share to Heart Failure

Share to Histones

Share to Myocytes, Cardiac

Source

Open in PubMed Open full text

Identifiers

PMID: 34273410
DOI: 10.1016/j.yjmcc.2021.07.002
PMCID: PMC9181638

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Early adaptive chromatin remodeling events precede pathologic phenotypes and are reinforced in the failing heart.PMID 34273410Read ↗

A Conserved Stress-Inducible Hub Enhancer Governs Natriuretic Peptide Expression and Undergoes Dynamic and Reversible Activation in Human Heart FailureSemantic proximity Read ↗

Epigenomic regulation of heart failure: integrating histone marks, long noncoding RNAs, and chromatin architectureSemantic proximity Read ↗

Genome-Wide Fetalization of Enhancer Architecture in Heart DiseaseSemantic proximity Read ↗

Epigenomes of Human Hearts Reveal New Genetic Variants Relevant for Cardiac Disease and Phenotype.Semantic proximity Read ↗

Single cell multiomics and 3D genome architecture reveal novel pathways of human heart failureSemantic proximity Read ↗

H3K27ac acetylome signatures reveal the epigenomic reorganization in remodeled non-failing human heartsSemantic proximity Read ↗

Transcriptional and Epigenetic Landscape of Cardiac Pacemaker Cells: Insights Into Cellular Specialization in the Sinoatrial NodeSemantic proximity Read ↗

Chromatin modifications remodel cardiac gene expressionSemantic proximity Read ↗

The atlas of human cardiac promoters and enhancers reveals an important role for regulatory elements in heart failureSemantic proximity Read ↗

Leveraging clinical epigenetics in heart failure with preserved ejection fraction: a call for individualized therapiesSemantic proximity Read ↗

Distinct epigenetic programs regulate cardiac myocyte development and disease in the human heart <i>in vivo</i>Semantic proximity Read ↗

The PTIP-Associated Histone Methyltransferase Complex Prevents Stress-Induced Maladaptive Cardiac RemodelingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.