Article

Transcriptional regulation profiling reveals disrupted lipid metabolism in failing hearts with a pathogenic phospholamban mutation

2020-12-01

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> The R14del mutation in the phospholamban ( PLN ) gene is associated with various types of cardiomyopathies and increases the risk of developing life-threatening ventricular arrhythmias. In this study, we focused on a homogeneous Dutch founder cohort of genetic cardiomyopathy due to PLN R14del mutation and aimed to study the influence of epigenetic changes from a multi-dimen...

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Literature Corpus work: 1bde4a13-ee55-58e5-81b2-d45efa74091c
DOI: 10.1101/2020.11.30.402792

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