Article

Genome-Wide DNA Methylation Profiling of the Failing Human Heart with Mechanical Unloading Identifies <i>LINC00881</i> as an Essential Regulator of Calcium Handling in the Cardiomyocyte

2022-03-02

Abstract excerpt

<h4>Background</h4> Human heart failure is characterized by global alterations in the myocardial DNA methylation profile, yet little is known about epigenetic regulation of non-coding transcripts and potential reversibility of DNA methylation with left ventricular assist device (LVAD) support. <h4>Method</h4> Genome-wide mapping of myocardial DNA methylation was performed in 36 patients with end-stage heart fail...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 77771743-67c6-5914-83c4-d49dd4fbee32
DOI: 10.1101/2022.03.01.482163

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genome-Wide DNA Methylation Profiling of the Failing Human Heart with Mechanical Unloading Identifies <i>LINC00881</i> as an Essential Regulator of Calcium Handling in the CardiomyocyteDOI 10.1101/2022.03.01.482163Read

Effect of mechanical unloading on genome-wide DNA methylation profile of the failing human heartSemantic proximity Read

Targeted DNA Methylation Profiling of Human Cardiac Tissue Reveals Novel Epigenetic Traits and Gene Deregulation Across Different Heart Failure Patient SubtypesSemantic proximity Read

Comparative transcriptomics analysis of histone deacetylases, transcription factors, and ion channel genes in human iPSC-cardiomyocytes vs. the adult human heartSemantic proximity Read

Epigenome-Wide Association Study Identifies Cardiac Gene Patterning and a Novel Class of Biomarkers for Heart Failure.Semantic proximity Read

Epigenomes of Human Hearts Reveal New Genetic Variants Relevant for Cardiac Disease and Phenotype.Semantic proximity Read

Epigenome-wide association study for dilated cardiomyopathy in left ventricular heart tissue identifies putative gene sets associated with cardiac development and early indicators of cardiac riskSemantic proximity Read

Dynamic DNA methylation orchestrates cardiomyocyte development, maturation and disease.Semantic proximity Read

Distinct epigenetic programs regulate cardiac myocyte development and disease in the human heart <i>in vivo</i>Semantic proximity Read

Integrative DNA methylome and transcriptome analysis identify potential genes on the influence of dilated cardiomyopathy-associated heart failureSemantic proximity Read

Distinct Epigenomic Features in End-Stage Failing Human HeartsSemantic proximity Read

Integrative analysis of transcriptome, DNA methylome, and chromatin accessibility reveals candidate therapeutic targets in hypertrophic cardiomyopathySemantic proximity Read