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Chromatin modifications remodel cardiac gene expression

8 May 2014

Abstract excerpt

Signalling and transcriptional control involve precise programmes of gene activation and suppression necessary for cardiovascular physiology. Deep sequencing of DNA-bound transcription factors reveals a remarkable complexity of co-activators or co-repressors that serve to alter chromatin modification and regulate gene expression. The regulated complexes characterized by genome-wide mapping implicate the...

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PMID: 24812277
DOI: 10.1093/cvr/cvu122

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