Article
ETV6 gene aberrations in non-haematological malignancies: A review highlighting ETV6 associated fusion genes in solid tumors.
Biochimica et biophysica acta. Reviews on cancer - 1 Aug 2020
Biswas Angana, Rajesh Yetirajam, Mitra Pralay, Mandal Mahitosh
Abstract excerpt
ETV6 (translocation-Ets-leukemia virus) gene is a transcriptional repressor mainly involved in haematopoiesis and maintenance of vascular networks and has developed to be a major oncogene with the potential ability of forming fusion partners with many other genes with carcinogenic consequences. ETV6 fusions function primarily by constitutive activation of kinase activity of the fusion partners, modifications in...
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