Article
Characterization of leukemias with ETV6-ABL1 fusion.
Haematologica - 1 Sept 2016
Zaliova Marketa, Moorman Anthony V, Cazzaniga Giovanni, Stanulla Martin, Harvey Richard C, Roberts Kathryn G, Heatley Sue L, Loh Mignon L, Konopleva Marina, Chen I-Ming, Zimmermannova Olga, Schwab Claire, Smith Owen, Mozziconacci Marie-Joelle, Chabannon Christian, Kim Myungshin, Frederik Falkenburg J H, Norton Alice, Marshall Karen, Haas Oskar A, Starkova Julia, Stuchly Jan, Hunger Stephen P, White Deborah, Mullighan Charles G, Willman Cheryl L, Stary Jan, Trka Jan, Zuna Jan
Abstract excerpt
To characterize the incidence, clinical features and genetics of ETV6-ABL1 leukemias, representing targetable kinase-activating lesions, we analyzed 44 new and published cases of ETV6-ABL1-positive hematologic malignancies [22 cases of acute lymphoblastic leukemia (13 children, 9 adults) and 22 myeloid malignancies (18 myeloproliferative neoplasms, 4 acute myeloid leukemias)]. The presence of the ETV6-ABL1 fusion...
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