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Exploration of ETV6::ABL1-positive AML with concurrent NPM1 and FLT3-ITD mutations.

Annals of hematology - 1 Oct 2024

Li Hui-Dan, Chen Si-Si, Ding Jing, Zhang Chun-Ling, Qiu Hui-Yin, Xia Xin-Xin, Yang Jun, Wang Xiao-Rui

Abstract excerpt

ETV6::ABL1 is a rare fusion gene that found in MPN, ALL, and AML. It has a complex and diverse formation mechanism due to the reciprocal orientations of the ETV6 and ABL1 genes relative to the centromeres. NPM1 is frequently mutated in adult AML, often accompanied by FLT3-ITD, which suggests molecular synergisms in AML pathogenesis. Previous reports on ETV6::ABL1 mostly focus on FLT3-ITD. In this study, we...

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PMID: 39105739
DOI: 10.1007/s00277-024-05917-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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