Article
Acute myeloid leukemia carrying ETV6 mutations: biologic and clinical features.
Hematology (Amsterdam, Netherlands) - 1 Oct 2018
Zhou Fang, Chen Baoan
Abstract excerpt
OBJECTIVES: E26 transformation-specific variant 6 gene (ETV6) is one of the most consistently rearranged genes in acute leukaemia. It encodes a principal hematopoietic transcription factor. METHODS: We performed a systematic review focusing on the mechanisms responsible for etv6 acquisition, and its effect on the development of AML. We also review the Characteristics of ETV6 mutations and its fusion genes....
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