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Fusion genes in cancers: Biogenesis, functions, and therapeutic implications

20 Jan 2025

Abstract excerpt

The processes of tumorigenesis and development are intricate, involving numerous genes and molecular pathways. Fusion genes, direct products of abnormal chromosomal rearrangements, are key factors in the formation of many types of tumors. In recent years, the advent of sequencing technology and bioinformatics has led to the discovery of more fusion genes associated with specific types of tumors. The objective of...

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PMID: 40584293
DOI: 10.1016/j.gendis.2025.101536

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