Article
Elevated In Vitro Kinase Activity in Peripheral Blood Mononuclear Cells of Leucine-Rich Repeat Kinase 2 G2019S Carriers: A Novel Enzyme-Linked Immunosorbent Assay-Based Method.
Movement disorders : official journal of the Movement Disorder Society - 1 Nov 2020
Melachroinou Katerina, Kang Min Suk, Liong Christopher, Narayan Sushma, Levers Najah, Joshi Neal, Kopil Katie, Hutten Samantha J, Baptista Marco A S, Padmanabhan Shalini, Kang Un Jung, Stefanis Leonidas, Alcalay Roy N, Rideout Hardy J
Abstract excerpt
BACKGROUND: Leucine-rich repeat kinase 2 kinase inhibitors are being vigorously pursued as potential therapeutic options; however, there is a critical need for sensitive and quantitative assays of leucine-rich repeat kinase 2 function and target engagement. OBJECTIVES: Our objective was to compare collection and storage protocols for peripheral blood mononuclear cells, and to determine the optimal conditions for...
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