Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Current State-of-the Art of LRRK2-Based Biomarker Assay Development in Parkinson’s Disease

18 Aug 2020

Abstract excerpt

Evidence is mounting that LRRK2 activity, particularly its kinase activity, is elevated in multiple forms of Parkinson’s disease, both idiopathic as well as familial forms linked to mutations in the LRRK2 gene. However, sensitive quantitative markers of LRRK2 activation in clinical samples remain at the early stages of development. There are several measures of LRRK2 activity that could potentially be used in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Parkinson's Disease Mechanisms and Treatments

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 33013290
DOI: 10.3389/fnins.2020.00865

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Current State-of-the Art of LRRK2-Based Biomarker Assay Development in Parkinson’s DiseasePMID 33013290Read ↗

Targeting LRRK2 in Parkinson's disease: an update on recent developments.Semantic proximity Read ↗

Role of LRRK2 kinase activity in the pathogenesis of Parkinson's disease.Semantic proximity Read ↗

Understanding LRRK2 kinase activity in preclinical models and human subjects through quantitative analysis of LRRK2 and pRab10Semantic proximity Read ↗

Pharmacodynamic Biomarkers for Emerging LRRK2 TherapeuticsSemantic proximity Read ↗

Role of LRRK2 in physiological activities, diseases, and therapy.Semantic proximity Read ↗

An Assessment of LRRK2 Serine 935 Phosphorylation in Human Peripheral Blood Mononuclear Cells in Idiopathic Parkinson’s Disease and G2019S LRRK2 CohortsSemantic proximity Read ↗

Leucine-rich repeat kinase 2 (LRRK2): an update on the potential therapeutic target for Parkinson’s diseaseSemantic proximity Read ↗

Precision Stratification: Kinase Assay in Asian <i>LRRK2</i> Risk Carriers and Idiopathic Parkinson DiseaseSemantic proximity Read ↗

Understanding LRRK2 kinase activity in preclinical models and human subjects through quantitative analysis of LRRK2 and pT73 Rab10Semantic proximity Read ↗

Distinct profiles of LRRK2 activation and Rab GTPase phosphorylation in clinical samples from different PD cohortsSemantic proximity Read ↗

Recent advances in targeting LRRK2 for Parkinson's disease treatment.Semantic proximity Read ↗

LRRK2 in Parkinson's disease: upstream regulation and therapeutic targeting.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.