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Article

Evaluation of Current Methods to Detect Cellular Leucine-Rich Repeat Kinase 2 (LRRK2) Kinase Activity.

Journal of Parkinson's disease - 1 Jan 2022

Fernández Belén, Chittoor-Vinod Vinita G, Kluss Jillian H, Kelly Kaela, Bryant Nicole, Nguyen An Phu Tran, Bukhari Syed A, Smith Nathan, Lara Ordóñez Antonio Jesús, Fdez Elena, Chartier-Harlin Marie-Christine, Montine Thomas J, Wilson Mark A, Moore Darren J, West Andrew B, Cookson Mark R, Nichols R Jeremy, Hilfiker Sabine

Abstract excerpt

BACKGROUND: Coding variation in the Leucine rich repeat kinase 2 gene linked to Parkinson's disease (PD) promotes enhanced activity of the encoded LRRK2 kinase, particularly with respect to autophosphorylation at S1292 and/or phosphorylation of the heterologous substrate RAB10. OBJECTIVE: To determine the inter-laboratory reliability of measurements of cellular LRRK2 kinase activity in the context of wildtype or...

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Identifiers

PMID: 35599495
DOI: 10.3233/JPD-213128
PMCID: PMC9398093

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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