Article
Investigation of leucine-rich repeat kinase 2 : enzymological properties and novel assays.
The FEBS journal - 1 Jan 2009
Anand Vasanti S, Reichling Laurie J, Lipinski Kerri, Stochaj Wayne, Duan Weili, Kelleher Kerry, Pungaliya Pooja, Brown Eugene L, Reinhart Peter H, Somberg Richard, Hirst Warren D, Riddle Steven M, Braithwaite Steven P
Abstract excerpt
Mutations in leucine-rich repeat kinase 2 (LRRK2) comprise the leading cause of autosomal dominant Parkinson's disease, with age of onset and symptoms identical to those of idiopathic forms of the disorder. Several of these pathogenic mutations are thought to affect its kinase activity, so understanding the roles of LRRK2, and modulation of its kinase activity,may lead to novel therapeutic strategies for treating...
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