Article
CD33 and SIGLECL1 Immunoglobulin Superfamily Involved in Dementia.
Journal of neuropathology and experimental neurology - 1 Aug 2020
Rendina Antonella, Drongitis Denise, Donizetti Aldo, Fucci Laura, Milan Graziella, Tripodi Francesca, Giustezza Francesca, Postiglione Alfredo, Pappatà Sabina, Ferrari Raffaele, Bossù Paola, Angiolillo Antonella, di Costanzo Alfonso, Caiazzo Massimiliano, Vitale Emilia
Abstract excerpt
Sialic acid-binding immunoglobulin-type lectins, which are predominantly expressed in immune cells, represent a family of immunomodulatory receptors with inhibitory and activating signals, in both healthy and disease states. Genetic factors are important in all forms of dementia, especially in early onset dementia. CD33 was recently recognized as a genetic risk factor for Alzheimer disease (AD). Here, we present...
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