Article
CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology.
Nature neuroscience - 1 Jul 2013
Bradshaw Elizabeth M, Chibnik Lori B, Keenan Brendan T, Ottoboni Linda, Raj Towfique, Tang Anna, Rosenkrantz Laura L, Imboywa Selina, Lee Michelle, Von Korff Alina, Morris Martha C, Evans Denis A, Johnson Keith, Sperling Reisa A, Schneider Julie A, Bennett David A, De Jager Philip L
Abstract excerpt
In our functional dissection of the CD33 Alzheimer's disease susceptibility locus, we found that the rs3865444(C) risk allele was associated with greater cell surface expression of CD33 in the monocytes (t50 = 10.06, P(joint) = 1.3 × 10(-13)) of young and older individuals. It was also associated with diminished internalization of amyloid-β 42 peptide, accumulation of neuritic amyloid pathology and fibrillar...
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