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Article

Angiocrine Sphingosine-1-Phosphate Activation of S1PR2-YAP Signaling Axis in Alveolar Type II Cells Is Essential for Lung Repair.

Cell reports - 30 Jun 2020

Chen Qian, Rehman Jalees, Chan Manwai, Fu Panfeng, Dudek Steven M, Natarajan Viswanathan, Malik Asrar B, Liu Yuru

Abstract excerpt

Lung alveolar epithelium is composed of alveolar type I (AT1) and type II (AT2) cells. AT1 cells mediate gas exchange, whereas AT2 cells act as progenitor cells to repair injured alveoli. Lung microvascular endothelial cells (LMVECs) play a crucial but still poorly understood role in regulating alveolar repair. Here, we studied the role of the LMVEC-derived bioactive lipid sphingosine-1-phosphate (S1P) in...

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Identifiers

PMID: 32610129
DOI: 10.1016/j.celrep.2020.107828
PMCID: PMC7371431

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