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Article

Targeting Macrophage Crosstalk to PASMC by Blunting Inflammatory Phenotype Via SerpinB1 Protects Against Hypoxia-Induced Pulmonary Hypertension.

Hypertension (Dallas, Tex. : 1979) - 1 Mar 2026

Hao Jiajin, Fang Guangyao, Li Xiuchuan, Wang Ting, Peng Ke, Liu Jincheng, Yang Dachun, Kang Xia, Wang Qiang, Yang Yongjian, Lan Cong

Abstract excerpt

BACKGROUND: Perivascular macrophages play a significant role in the pathogenesis of hypoxia-induced pulmonary hypertension via crosstalk to pulmonary artery smooth muscle cells (PASMCs) to stimulate their proliferation and pulmonary vascular remodeling. However, whether hypoxia exposure of macrophages affects cellular crosstalk remains entirely unclear. This study aimed to decipher the effects of hypoxia on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Muscle, Smooth, Vascular

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Share to Vascular Remodeling

Source

Identifiers

PMID: 41498134
DOI: 10.1161/HYPERTENSIONAHA.125.25832

Genes

NLRP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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