SHIP‐1, a target of miR‐155, regulates endothelial cell responses in lung fibrosis

Abstract excerpt

Src Homology 2-containing Inositol Phosphatase-1 (SHIP-1) is a target of miR-155, a pro-inflammatory factor. Deletion of the SHIP-1 gene in mice caused spontaneous lung inflammation and fibrosis. However, the role and function of endothelial miR-155 and SHIP-1 in lung fibrosis remain unknown. Using whole-body miR-155 knockout mice and endothelial cell-specific conditional miR-155 (VEC-Cre-miR-155 or VEC-miR-155)...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Extracellular vesicles in disease
• Share to Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
• Share to MicroRNA in disease regulation