Endothelial-Specific Loss of Sphingosine-1-Phosphate Receptor 1 Increases Vascular Permeability and Exacerbates Bleomycin-induced Pulmonary Fibrosis.

doi:10.1165/rcmb.2020-0408OC

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Article

Endothelial-Specific Loss of Sphingosine-1-Phosphate Receptor 1 Increases Vascular Permeability and Exacerbates Bleomycin-induced Pulmonary Fibrosis.

American journal of respiratory cell and molecular biology - 1 Jan 2022

Knipe Rachel S, Spinney Jillian J, Abe Elizabeth A, Probst Clemens K, Franklin Alicia, Logue Amanda, Giacona Francesca, Drummond Matt, Griffith Jason, Brazee Patricia L, Hariri Lida P, Montesi Sydney B, Black Katherine E, Hla Timothy, Kuo Andrew, Cartier Andreane, Engelbrecht Eric, Christoffersen Christina, Shea Barry S, Tager Andrew M, Medoff Benjamin D

Abstract excerpt

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive disease which leads to significant morbidity and mortality from respiratory failure. The two drugs currently approved for clinical use slow the rate of decline in lung function but have not been shown to halt disease progression or reverse established fibrosis. Thus, new therapeutic targets are needed. Endothelial injury and the resultant vascular...

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Identifiers

PMID: 34343038
DOI: 10.1165/rcmb.2020-0408OC
PMCID: PMC8803357

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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