Article

S1pr1 serves as a viable drug target against pulmonary fibrosis by increasing the integrity of the endothelial barrier of the lung

2022-04-13

Abstract excerpt

<h4>Background: </h4> and Purpose：As important components of lung tissue, endothelial cells (ECs) are associated with many lung diseases. The role of ECs dysfunction in idiopathic pulmonary fibrosis (IPF) and how to improve alveolar capillary barrier (ACB) to treat IPF is incompletely understood. Therefore we investigated the involvment of endothelial Sphingosine-1-phosphate receptor 1 (S1pr1) in PF and therapeuti...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5cb0b0af-9411-5c0f-9ee7-63ba456a3f16
DOI: 10.22541/au.164982264.48573643/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

S1pr1 serves as a viable drug target against pulmonary fibrosis by increasing the integrity of the endothelial barrier of the lungDOI 10.22541/au.164982264.48573643/v1Read

Endothelial-Specific Loss of Sphingosine-1-Phosphate Receptor 1 Increases Vascular Permeability and Exacerbates Bleomycin-induced Pulmonary Fibrosis.Semantic proximity Read

Angiocrine Sphingosine-1-Phosphate Activation of S1PR2-YAP Signaling Axis in Alveolar Type II Cells Is Essential for Lung Repair.Semantic proximity Read

Updated perspective of EPAS1 and the role in pulmonary hypertensionSemantic proximity Read

[Pulmonary hypertension: from molecular pathophysiology to haemodynamic abnormalities].Semantic proximity Read

Myeloid Cell Derived IL1β Contributes to Pulmonary Vascular Remodeling in Heart Failure with Preserved Ejection FractionSemantic proximity Read

Prognostic value of S1PR1 and Correlations with Immune Infiltrates in Breast and Lung CancersSemantic proximity Read

Critical role of sphingosine-1-phosphate receptor 2 (S1PR2) in acute vascular inflammation.Semantic proximity Read

Modulating Sphingosine-1-Phosphate receptors to improve chemotherapy delivery to Ewing sarcomaSemantic proximity Read

Abnormal lymphatic S1P signaling aggravates lymphatic dysfunction and tissue inflammationSemantic proximity Read

SHIP‐1, a target of miR‐155, regulates endothelial cell responses in lung fibrosisSemantic proximity Read

CD248 activates TGF-β receptor I to promote vascular remodeling in pulmonary arterial hypertensionSemantic proximity Read

Targeting Macrophage Crosstalk to PASMC by Blunting Inflammatory Phenotype Via SerpinB1 Protects Against Hypoxia-Induced Pulmonary Hypertension.Semantic proximity Read