Article

Abnormal lymphatic S1P signaling aggravates lymphatic dysfunction and tissue inflammation

2023-06-12

Abstract excerpt

<h4>BACKGROUND</h4> Lymphedema is a global health problem with no effective drug treatment. Enhanced T cell immunity and abnormal lymphatic endothelial cell (LEC) signaling are promising therapeutic targets for this condition. Sphingosine-1-phosphate (S1P) mediates a key signaling pathway required for normal LEC function, and altered S1P signaling in LECs could lead to lymphatic disease and pathogenic T cell activ...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7fb8f1f3-9b14-5f0a-87c6-b4d1efe37222
DOI: 10.1101/2023.06.08.23291175

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Abnormal lymphatic S1P signaling aggravates lymphatic dysfunction and tissue inflammationDOI 10.1101/2023.06.08.23291175Read

S1PR1 Regulates Lymphatic Valve Development And Prevents Ileitis-Independent Tertiary Lymphoid Organ FormationSemantic proximity Read

Developmental and pathological lymphangiogenesis: from models to human diseaseSemantic proximity Read

Single-cell RNA-seq of the stromal vascular fraction of adipose tissue reveals lineage-specific changes in cancer-related lymphedemaSemantic proximity Read

Lymphatic vessel: Origin, heterogeneity, biological functions and therapeutic targetsSemantic proximity Read

Current Mechanistic Understandings of Lymphedema and Lipedema: Tales of Fluid, Fat, and FibrosisSemantic proximity Read

New developments in clinical aspects of lymphatic disease.Semantic proximity Read

The lymphatics and the inflammatory response: lessons learned from human lymphedema.Semantic proximity Read

Molecular regulation of lymphangiogenesis and targets for tissue oedemaSemantic proximity Read

Genome-wide functional analysis reveals central signaling regulators of lymphatic endothelial cell migration and remodelingSemantic proximity Read

<i>Animal Models for the Molecular and Mechanistic Study of Lymphatic Biology and Disease</i>Semantic proximity Read

Multi-level analysis of adipose tissue reveals the relevance of perivascular subpopulations and an increased endothelial permeability in early-stage lipedemaSemantic proximity Read

Immunoregulatory subtype of dermal lymphatic endothelial cells at capillary terminals drives lymphatic malformationsSemantic proximity Read