Article
Critical role of sphingosine-1-phosphate receptor 2 (S1PR2) in acute vascular inflammation.
Blood - 18 Jul 2013
Zhang Guoqi, Yang Li, Kim Gab Seok, Ryan Kieran, Lu Shulin, O'Donnell Rebekah K, Spokes Katherine, Shapiro Nathan, Aird William C, Kluk Michael J, Yano Kiichiro, Sanchez Teresa
Abstract excerpt
The endothelium, as the interface between blood and all tissues, plays a critical role in inflammation. Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid, highly abundant in plasma, that potently regulates endothelial responses through interaction with its receptors (S1PRs). Here, we studied the role of S1PR2 in the regulation of the proadhesion and proinflammatory phenotype of the endothelium. By using...
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