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Article

Upregulation of Angiomotin-Like 2 Ameliorates Experimental Pulmonary Arterial Hypertension by Inactivating YAP1 Signaling.

Journal of cardiovascular pharmacology - 1 Sept 2024

Deng Jizhao, Yang Guang, Zhong Nier, Liang Lei, Chen Haichao

Abstract excerpt

ABSTRACT: Angiomotin-like 2 (AMOTL2) is related to numerous physiological and pathological conditions by affecting signal transduction. However, whether AMOTL2 is linked to pulmonary arterial hypertension (PAH) has not been addressed. This work aimed to investigate the potential role of AMOTL2 in PAH. A decrease in AMOTL2 abundance was observed in the lungs of PAH rats. The upregulation of AMOTL2 significantly...

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Topics

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Share to Arterial Pressure
Share to Muscle, Smooth, Vascular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Myocytes, Smooth Muscle

Share to Pulmonary Arterial Hypertension

Share to Pulmonary Artery

Share to Vascular Remodeling

Share to Ventricular Function, Right

Share to YAP-Signaling Proteins

Source

Identifiers

PMID: 39027975
DOI: 10.1097/FJC.0000000000001606

Genes

AMOTL2
PAH
YAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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