Article
The role of Rif1 in telomere length regulation is separable from its role in origin firing.
eLife - 29 Jun 2020
Shubin Calla B, Greider Carol W
Abstract excerpt
To examine the established link between DNA replication and telomere length, we tested whether firing of telomeric origins would cause telomere lengthening. We found that RIF1 mutants that block Protein Phosphatase 1 (PP1) binding activated telomeric origins but did not elongate telomeres. In a second approach, we found overexpression of ∆N-Dbf4 and Cdc7 increased DDK activity and activated telomeric origins, yet...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.