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Article

Rif1 Regulates the Fate of DNA Entanglements during Mitosis

1 Jun 2016

Abstract excerpt

Clearance of entangled DNA from the anaphase mid-region must accurately proceed in order for chromosomes to segregate with high fidelity. Loss of Taz1 (fission yeast ortholog of human TRF1/TRF2) leads to stalled telomeric replication forks that trigger telomeric entanglements; the resolution of these entanglements fails at ≤20°C. Here, we investigate these entanglements and their promotion by the conserved...

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Share to DNA Repair Mechanisms
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Identifiers

PMID: 27320927
DOI: 10.1016/j.celrep.2016.05.077

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Rif1 Regulates the Fate of DNA Entanglements during MitosisPMID 27320927Read ↗

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Elevated levels of TRF2 induce telomeric ultrafine anaphase bridges and rapid telomere deletionsSemantic proximity Read ↗

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