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Article

Rif1 controls DNA replication by directing Protein Phosphatase 1 to reverse Cdc7-mediated phosphorylation of the MCM complex.

Genes & development - 15 Feb 2014

Hiraga Shin-Ichiro, Alvino Gina M, Chang Fujung, Lian Hui-Yong, Sridhar Akila, Kubota Takashi, Brewer Bonita J, Weinreich Michael, Raghuraman M K, Donaldson Anne D

Abstract excerpt

Initiation of eukaryotic DNA replication requires phosphorylation of the MCM complex by Dbf4-dependent kinase (DDK), composed of Cdc7 kinase and its activator, Dbf4. We report here that budding yeast Rif1 (Rap1-interacting factor 1) controls DNA replication genome-wide and describe how Rif1 opposes DDK function by directing Protein Phosphatase 1 (PP1)-mediated dephosphorylation of the MCM complex. Deleting RIF1...

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Identifiers

PMID: 24532715
DOI: 10.1101/gad.231258.113
PMCID: PMC3937515

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Rif1 controls DNA replication by directing Protein Phosphatase 1 to reverse Cdc7-mediated phosphorylation of the MCM complex.PMID 24532715Read ↗

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The peptidyl prolyl isomerase Rrd1 regulates the elongation of RNA polymerase II during transcriptional stresses.Semantic proximity Read ↗

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